Endocrine Abstracts

Background & Aims: An increased prevalence of obesity among patients with prolactinoma (PR) and weight loss after treatment (specially in male patients) has been reported1,2. On the other hand, weight gain after treatment has been observed in another study3. In this study we looked at the evolution of body weight in 37 patients with PR, 22 macroprolactinomas (MAPR) and 15 microprolactinomas (MIPR).Methods: We conducted a retrospective s...

Introduction. Adiponectin is a novel circulating adipocyte derived protein, whose plasma concentrations paradoxically decrease with increasing fat mass. Adiponectin has been shown to improve both glucose and lipid metabolism, and circulating concentrations are inversely correlated with insulin resistance. The factors regulating adiponectin expression and secretion are poorly understood. No study has previously examined the acute post-prandial regulation of adiponectin s...

Background: numerous studies using a variety of quality of life (QOL) measures have shown multiple impairments in adults with growth hormone deficiency (GHD) compared to control subjects. There have been few studies however of QOL in a treated GHD population compared with healthy controls.Method: 120 adults with treated GHD ( >1 year) were given the following QOL questionnaires at annual review: SF36, Nottingham Health Profile, Disease Impact, Life F...

Background: We previously demonstrated that elderly patients with GHD have increased and young GHD patients have reduced cardiac sympathovagal balance. Therefore we decided to investigate whether the relationship between age and cardiac sympathovagal balance is altered in GHD compared to healthy controls.Method: HRV, which indirectly measures cardiac sympathovagal balance, was measured in 22 untreated GHD patients (13 F; mean age 47.4 yrs; range 19-73 y...

The multisystem disorder POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a rare plasma cell dyscrasia. Elevated cytokines may contribute to its pathogenesis. We describe a POEMS patient with elevated plasma cytokines and excessive daytime sleepiness (EDS).A 39-year-old white woman with IgA lambda and IgG kappa paraproteinaemia, peripheral axonal sensorimotor neuropathy, moderate anascara, skin thickening a...